［2018］犬の過敏症多動症候群に関するレトロスペクティブ研究：フルオキセチン大量投与の長期成績と臨床スコアの提案

Retrospective study on hypersensitivity-hyperactivity syndrome in dogs: long-term outcome of high dose fluoxetine treatment and proposal of a clinical score

書誌情報Masson, S. & Gaultier, E. Retrospective study on hypersensitivity-hyperactivity syndrome in dogs: Long-term outcome of high dose fluoxetine treatment and proposal of a clinical score. Dog Behav. 4, 15–35 (2018).
https://doi.org/10.4454/db.v4i2.79

Notice

表題の論文を日本語訳してみました。翻訳アプリにかけた日本語訳を英文に照らして修正していますが、表記のゆれや訳の間違いがあるかもしれません。正確に内容を知りたい方は、原文をご覧ください。

Abstract：要旨

In the French veterinary psychiatry model, the canine version of attention deficit hyperactivity disorder is called hypersensitivity-hyperactivity syndrome (HSHA) and it includes two stages, depending on the symptom severity.

フランスの獣医精神医学モデルでは、注意欠陥多動性障害の犬バージョンは過敏性多動症候群（HSHA）と呼ばれ、症状の重症度に応じて2つの段階がある。

Since methylphenidate is not authorized for veterinary use in France, HSHA dogs are commonly treated with 2 to 4 mg/kg fluoxetine associated with behavioural modifications.

フランスではメチルフェニデートは動物用医薬品として認可されていないため、HSHA犬には一般的に2～4mg/kgのフルオキセチンを投与し、行動学的な修正を加えている。

Thus, the aim of this study was to analyze the long-term outcome of this global approach. Twenty-four dogs diagnosed with HSHA were included.

したがって、この研究の目的は、このグローバルなアプローチの長期的転帰を分析することであった。HSHAと診断された24頭の犬を対象とした。

For each dog, 42 descriptive data were analyzed. Primary reasons for consulting were variable if the dogs had an additionnal behavioural diagnosis (i.e. 33% of the dogs): complaints were linked to the comorbid diagnosis (e.g. bite on strangers, people phobia), whereas they were linked to autocontrol deficiency for the dogs diagnosed with HSHA only (e.g. destructive, mouth, jumps on people).

それぞれの犬について、42の記述的データが分析された。主な受診理由は、行動学的診断が併存している犬（33％）については様々であった：愁訴は併存診断と関連していた（例：他人への咬みつき、対人恐怖症）のに対し、HSHAと診断された犬のみでは自制不全と関連していた（例：破壊的、口、人への飛びつき）。

HSHA affection deeply alters the dog-human bond, as severe cases often lead owners to think about euthanasia or rehoming (12% for stage 1, but 83% for stage 2).

HSHAの愛情は犬と人間の絆を深く変化させ、重症例では飼い主が安楽死や再飼育を考えるようになることが多い（ステージ1では12％、ステージ2では83％）。

Neither the possibility to have access to a garden nor the quantity of daily exercise were linked to HSHA stages (respectively, Fisher’s exact test, p=0.69, and Kruskal-Wallis, p=0.88).

庭を利用できる可能性も、毎日の運動量も、HSHAの病期とは関連していなかった（それぞれ、Fisherの正確検定、p=0.69、Kruskal-Wallis、p=0.88）。

Eighty-three percent of the dogs attended training classes before consulting, with no noticeable improvement (mean training improvement score 1.7/10). In addition, training seemed even less efficient on severe cases, i.e. stage 2 dogs (Kruskall-Wallis, p<0.03).

83％の犬が相談前にトレーニングクラスに参加したが、顕著な改善は見られなかった（平均トレーニング改善スコア1.7/10）。さらに、重症例、すなわちステージ2の犬では、トレーニングの効率はさらに低いようであった（Kruskall-Wallis、p<0.03）。

After two months of high dose fluoxetine (2 to 4 mg/kg), the average score of improvement given by owners was 7.2/10 compared to 0/10 at start. No long-term adverse effect was reported.

高用量のフルオキセチン（2～4mg/kg）を2ヵ月間投与した結果、飼い主の平均改善スコアは7.2/10であった（投与開始時は0/10）。長期的な副作用は報告されなかった。

A HSHA clinical score (0 to 5 scale) was built to better categorize the dogs and to conduct the follow-up. The HSHA clinical score was correlated to fluoxetine dose (Pearson correlation, p<0.01) and duration (Pearson correlation, p<0.05). A successful weaning from treatment was possible for 54% of the dogs.

HSHA臨床スコア（0〜5スケール）を作成し、犬の分類と経過観察を行った。HSHA臨床スコアはフルオキセチンの投与量（ピアソン相関、p<0.01）および投与期間（ピアソン相関、p<0.05）と相関していた。治療からの離脱が成功した犬は54％であった。

These results suggest that HSHA spectrum can range from mild clinical signs to widely pervasive and invalidating ones.

これらの結果は、HSHAのスペクトルが、軽度の臨床症状から、広く蔓延し無効となるものまで、さまざまであることを示唆している。

Starting the treatment as early as possible seems determinant for the welfare of the dog and for the dog-owner relationship, but doesn’t allow a shorter treatment (Kruskall-Wallis, p=0.84) or more chances for a weaning (Fisher’s exact test, p=0.88).

可能な限り早期に治療を開始することは、犬の福祉と犬と飼い主の関係を決定するようだが、治療期間を短縮したり（Kruskall-Wallis、p=0.84）、離乳の機会を増やすことはできない（Fisherの正確検定、p=0.88）。

However, high dose fluoxetine associated with behavioural modifications appear to be useful and well tolerated to treat this complex syndrome.

しかし、フルオキセチンの大量投与と行動修正との併用は、この複雑な症候群の治療に有用であり、忍容性も高いと思われる。

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Keywords:

dog, hyperactivity, impulsivity, hypersensitivity, hyperreactivity, fluoxetine, ADHD-like syndrome

Retrospective study on hypersensitivity-hyperactivity syndrome in dogs: long-term outcome of high dose fluoxetine treatment and proposal of a clinical score | Dog behavior